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簡介：NNC 55-0396是Mibefradil衍生物，是T型鈣離子通道阻斷劑。

NNC 55-0396物理化學(xué)性質(zhì)：

沸點(diǎn)	713.8oC at 760mmHg
分子式	C30H40Cl2FN3O2
分子量	564.562
閃點(diǎn)	385.5oC
精確質(zhì)量	563.248
PSA	58.22
LogP	7.6385

NNC 55-0396詳細(xì)介紹：

中文名稱：	1-溴-2-(二氟甲基)-4-氟苯
中文別名：	1-溴-2-(二氟甲基)-4-氟苯
英文名稱：	NNC 55-0396
英文別名：	Cyclopropanecarboxylicacid,(1S,2S)-2-[2-[[3-(1H-benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenylester, hydrochloride (1:2);(1S,2S)-2-[2-[[3-(1H-BENZIMIDAZOL-2-YL)PROPYL]METHYLAMINO]ETHYL]-6-FLUORO-1,2,3,4-TETRAHYDRO-1-(1-METHYLETHYL)-2-NAPHTHALENYL CYCLOPROPANECARBOXYLATE DIHYDROCHLORIDE;Cyclopropanecarboxylicacid,(1S,2S)-2-[2-[[3-(1H-benzimidazol-2-yl)propyl]methylamino]ethyl]-6-...;Cyclopropanecarboxylicacid,(1S,2S)-2-[2-[[3-(1H-benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-;NNC 55-0396 dihydrochloride;NNC 55-0396 dihydrochloride,(1S,2S)-2-[2-[[3-(1H-Benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenylcyclopropanecarboxylatedihydrochloride;NNC 55-0396
CAS號：	357400-13-6
分子式：	C30H38FN3O2.2CLH
分子量：	564.56
詳細(xì)描述：	博飛美科提供357400-13-6，NNC 55-0396，Perfemiker，上海現(xiàn)貨。 Medlife，致力于提供高品質(zhì)、高性價(jià)比小分子化合物的產(chǎn)品。 Medlife小分子化合物大量庫存，提供超過2萬種的抑制劑、激動劑、拮抗劑等產(chǎn)品，是藥物及疾病研究的重要原料供應(yīng)商。 T型鈣離子通道阻斷劑,NNC 55-0396是Mibefradil衍生物，是T型鈣離子通道阻斷劑。查詢關(guān)鍵詞:“357400-13-6，NNC 55-0396，PC11878，Perfemiker，上?，F(xiàn)貨”。

NNC 55-0396參考文獻(xiàn)：

[1]. Arnulfo Quesadaa, Peter H. Bui, Gregg E. Homanics，et al. Comparison of mibefradil and derivative NNC 55-0396 effects on behavior, cytochrome P450 activity, and tremor in mouse models of essential tremor. European Journal of Pharmacology. 2011,659 (1): 30-36.

[2]. Timo Strünker, Normann Goodwin, Christoph Brenker, et al. The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm. Nature, 2011,471, 382-386.

[3]. Hideto Miwa, Jinsoo Koh, Yoshinori Kajimoto, et al. Effects of T-type calcium channel blockers on a parkinsonian tremor model in rats. Pharmacology Biochemistry and Behavior. 2011,97(4): 656-659.

[4]. Li M, Hansen JB, Huang L, et al. Towards selective antagonists of T-type calcium channels: design, characterization and potential applications of NNC 55-0396. Cardiovasc Drug Rev. 2005 Summer;23(2):173-96.

[5]. Huang L, Keyser BM, Tagmose TM, et al. NNC 55-0396 [(1S,2S)-2-(2-(N-[(3-benzimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: a new selective inhibitor of T-type calcium channels. J Pharmacol Exp Ther. 2004 Apr;309(1):193-9.